Nuvo vs SiPhox Health: Daily Biological Age or Periodic Blood Panels?

Pick SiPhox Health for periodic at-home blood panels and a blood-biomarker biological age. Pick Nuvo for a daily 21-biomarker bio age on iPhone, $24.99/yr.

Written by the Nuvo Longevity editorial team at Firefly Labs LLC.

Choose SiPhox Health if you want a periodic at-home blood membership: mail an upper-arm sample, get a lab panel on a monthly, quarterly, or twice-yearly cadence, and read a biological age built from blood biomarkers in a SiPhox account. Choose Nuvo if you want a daily biological age on iPhone and Apple Watch from 21 biomarkers — HealthKit wearables plus optional conventional lab PDF — with on-device AI, no account, and $24.99/year after a 7-day trial. SiPhox is a blood-panel membership that also reports a blood-biomarker age. Nuvo is a daily on-device coach on the hardware you already carry. Many people who already pay for blood tests still want that daily 21-biomarker number; they can stack.

Written by the Nuvo Longevity editorial team at Firefly Labs LLC, the developer of Nuvo. SiPhox Health details below are taken from SiPhox’s public homepage, programs page, homepage FAQ, biological-age guide, Biological Age vs. Advanced Biological Age guide, Advanced Biological Age calculation guide, November 2025 cost article, wearable-integrations docs, and privacy policy, checked 28 September 2026. Where those pages disagree on price or biomarker count, we quote the page and do not invent a single checkout total. This page is educational and is not medical advice.

What each product actually sells

SiPhox Health: at-home blood panels and a blood-biomarker biological age

SiPhox Health (SiPhox, Inc.) sells a membership for at-home blood testing. The homepage (checked 28 September 2026) says you test at home with no lab visit, pick a panel each time, and get results in about 7–10 days. The homepage FAQ says the kit arrives in 3–5 days, collection is a small upper-arm sample that takes about 5 minutes (“no needles, no lab visits”), and the sample is processed at a CLIA-certified lab. A separate FAQ answer says results are typically ready 7–10 days after the sample reaches the lab, and that the partner lab holds CLIA certification and CAP accreditation. You choose a cadence — monthly, quarterly, or every 6 months — and the membership renews on that cadence. You can change cadence or cancel from the account portal. Membership is HSA/FSA eligible.

What the membership includes, per that same homepage FAQ: at-home blood testing with a choice of panel, personalized insights and an action plan, supplement recommendations, Sai (SiPhox’s AI health assistant), unlimited third-party lab uploads, wearable device integrations, and one dashboard. Four core panels are included and you can switch between them: Longevity Essentials, Thyroid Focus, Hormone Focus, and Heart & Metabolic. The FAQ says you can upgrade to Ultimate 360 “for up to 60 biomarkers in a single test.”

The live programs page on the same date labels panel sizes in the page controls: Longevity Essentials (35), Thyroid Focus (21), Hormone Focus (18), Heart & Metabolic (28), GLP Optimization Panel (46), and Ultimate 360 (65). GLP Optimization is shown as +$75 and Ultimate 360 as +$125. Those program-page counts do not match the homepage FAQ’s “up to 60” for Ultimate 360. We are not going to collapse 60 and 65 into one number.

Biological age is a blood result, not a morning wearable score. SiPhox’s Biological Age guide (last updated 27 August 2026) says the score examines patterns across blood biomarkers and estimates whether that pattern looks more like someone younger, older, or near your chronological age. The guide says the model was trained on large public health datasets and internal data, that it uses a subset of available biomarkers (at least about 50% required), and that it is not a medical diagnosis. The published male list names 26 markers (including HbA1c, 25-OH vitamin D, ALT, albumin, ApoA1, ApoB, lipids, hs-CRP, creatinine, and hormones such as DHEA-S and PSA). The female list names 25 markers and swaps in estradiol. The guide is explicit that the score does not capture every aging factor, including fitness, body composition, and sleep quality.

SiPhox also describes a second number. The Biological Age vs. Advanced Biological Age guide (same 27 August 2026 date) says Biological Age asks which age a biomarker pattern most resembles, and was trained on publicly available CDC data plus internal SiPhox data to predict chronological age from that pattern. Advanced Biological Age asks which age your predicted long-term disease risk matches. SiPhox says Advanced Biological Age comes from a partnership with VOLO Health, with models trained on long-term outcome data including the UK Biobank and US clinical records, then translated back into an age. The calculation guide says blood-work values are the only inputs to that report. A November 13, 2025 cost article instead says membership includes “BioAge and Heart & Metabolic Age scores.” That older article does not use the Advanced Biological Age name. We cite both and do not pretend they are one clock.

Wearables are context next to the labs. SiPhox’s wearable integrations docs say Apple Watch, Oura, Fitbit, Garmin, and others can sync sleep, activity, and related metrics into the SiPhox dashboard beside blood results. The docs also say SiPhox is not a replacement for the wearable’s own app. Connecting a watch does not turn SiPhox into a daily biological-age coach.

Nuvo: a daily 21-biomarker score

Nuvo Longevity (App Store: Nuvo: Longevity Coach, id 6762535065) is an iPhone and Apple Watch app. It calculates a daily biological age from 21 biomarkers: Apple Health / HealthKit data from Apple Watch, Oura, or Garmin, plus optional lab PDF upload so conventional results you already paid for (HbA1c, fasting glucose, HDL, CRP, creatinine, and more) sit in the same score.

Coaching runs as on-device private AI (Nuvo Intelligence). There is no account. Apple’s privacy nutrition label for Nuvo is Data Not Collected. Health data stays on the phone. Price is $4.99/month or $24.99/year after a 7-day trial — $24.99/year is $2.08/month billed annually. Nuvo is not Android, does not sell a blood-draw membership, and does not run SiPhox’s Biological Age or Advanced Biological Age models.

Nuvo is not SiPhox, a mailed blood panel, or a VOLO Health risk model. If the job is “send a blood sample on a membership cadence and get a lab panel plus a blood-biomarker biological age,” that is SiPhox. If the job is “one daily biological age from 21 biomarkers, including optional labs, privately, on the phone you already carry,” that is Nuvo. Download app. For the wider field, see our 2026 biological age app comparison. For a 160+ conventional lab membership rather than SiPhox’s at-home panels, see Nuvo vs Function Health. For an IgG glycan kit rather than a multi-marker blood panel, see Nuvo vs GlycanAge.

Comparison table

What the science actually measures

A blood-biomarker biological age is a model: clinical chemistry in, an age-like number out. It is a different measurement family from a DNA methylation clock, from an IgG glycan index, and from a wearable-plus-optional-lab composite that updates every day. SiPhox’s own August 2026 comparison guide points readers to that literature, including:

• Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study. PLoS Med. 2018;15(12):e1002718 — phenotypic age from clinical laboratory biomarkers in NHANES, associated with morbidity and mortality in that cohort.
• Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10(4):573–591 — the DNAm PhenoAge clock, trained in part on clinical biomarkers, then read from DNA methylation. That is not a wearable score and not SiPhox’s at-home panel by itself.

Those papers do not say a SiPhox dashboard number and a daily iPhone score are the same object. SiPhox’s Biological Age guide says their model was trained on public health datasets and internal data to estimate which age a biomarker pattern resembles. Their Advanced Biological Age guide says that second number comes from VOLO Health models trained on outcome data, with blood work as the input. Nuvo’s 21 biomarkers are wearable signals plus optional conventional labs — heart-rate variability, sleep, fitness, and markers such as HbA1c or CRP — recalculated daily. A SiPhox biological age of 41 and a Nuvo daily score of 41 are not interchangeable, even if both are labeled “biological age.” What “biological age” means next to calendar age is covered in biological age vs chronological age.

Can they stack?

Yes, as complementary layers — not as two skins of one clock. SiPhox is the periodic blood panel and the blood-biomarker age (and, if you have it, the Advanced Biological Age report). Nuvo is the daily trend on HealthKit plus optional conventional labs. Nuvo does not ingest SiPhox Biological Age, Advanced Biological Age, or a named SiPhox input. If you also have a standard lab PDF whose markers Nuvo reads (HbA1c, fasting glucose, HDL, CRP, creatinine, and similar), that PDF can sit in Nuvo’s 21-biomarker score. A SiPhox biological-age figure is still worth reading on its own; it is not a drop-in replacement for the wearable half of Nuvo, and Nuvo’s daily number is not a substitute for a CLIA blood panel.

Privacy

SiPhox is an account and lab product. To get results you join, ship a sample, and sign in. The privacy policy (last modified 6 June 2025) says it covers information collected when you use the SiPhox app and website, including health information you provide and data from wearables you connect. The homepage says SiPhox does not sell personal information and that you can delete your data. That is a normal design for a mailed blood membership. It is not Nuvo’s design.

Nuvo requires no account and uses the Apple privacy label Data Not Collected. Coaching is on-device. Data stays on the phone. If you will not put a blood panel on a lab account, do not buy SiPhox. If you will not put longitudinal wearable and lab data on an app account, Nuvo is the one built for that constraint. Architecture notes: health app privacy and on-device AI.

Where SiPhox wins

SiPhox wins if the job is a repeated at-home blood panel plus a biological age computed from those blood biomarkers. That is the product on the homepage and in the August 2026 guides: CLIA lab processing, panels you can switch (longevity, thyroid, hormone, heart and metabolic, or the Ultimate 360 upgrade), Sai in the dashboard, and a blood-only age model. Nuvo does not claim to beat SiPhox at drawing a panel, reporting ApoB or a hormone set, or producing SiPhox’s Advanced Biological Age report. If that is the product you came to buy, buy SiPhox.

SiPhox also wins on depth of a single blood time point. One draw is a lab snapshot. Nuvo’s daily number is a 21-biomarker composite you can actually see every morning. Those are different resolutions. Scale is not close on reviews either. Nuvo’s App Store presence is early: 4 ratings. We are not going to inflate four ratings into social proof, and we do not publish a schema.org rating object for Nuvo.

Where Nuvo wins

Nuvo wins on the daily biological-age job. SiPhox updates when you collect, ship, and wait about 7–10 days, on a cadence of months. Nuvo recalculates a daily biological age from 21 biomarkers so sleep, HRV, training, and optional labs can sit in one number without another kit.

Nuvo wins on price if you already own an iPhone (and often an Apple Watch) and you do not need a new blood draw. $24.99/year versus a SiPhox membership at the live $124 “Start testing” CTA — plus shipping and handling, and plus any Ultimate 360 or GLP add-on — is not a like-for-like discount. It is a category difference. If you do not want to mail blood, Nuvo does not require it.

Privacy is structural. SiPhox is account, lab, and cloud (registration, a blood sample, and wearable connections into that account). Nuvo is no account and Data Not Collected. Conventional labs in Nuvo are optional PDFs in the same 21-biomarker score. Those PDFs do not become SiPhox’s Biological Age, and SiPhox’s blood age does not become Nuvo’s daily clock.

Who wins for which user

Buy SiPhox if you want the at-home blood membership and will retest on a monthly, quarterly, or 6-month cadence. Buy Nuvo if you want a daily 21-biomarker biological age on iPhone and Apple Watch, privately, at $24.99/year. Buy both if you already pay for SiPhox and still want a daily age number from HealthKit plus any conventional lab PDF you have. They do not cancel each other; one is a periodic blood-biomarker age, the other is a daily age readout.

If the only job is “at-home blood panels and a biological age from those biomarkers,” stop at SiPhox. If the only job is “daily biological age from 21 biomarkers, privately, on iPhone,” stop at Nuvo. Download app.

Habits that actually move aging markers — sleep, aerobic fitness, glucose, inflammation — are covered in How to reduce biological age. This page is only about which product to buy for which job. For Function Health’s 160+ lab membership, see Nuvo vs Function Health. For GlycanAge’s IgG glycan kit, see Nuvo vs GlycanAge.

Pricing math without invented discounts

SiPhox public prices we could actually see on 28 September 2026 do not agree with each other, so this section quotes pages instead of picking a winner:

• Homepage primary button: $124 labeled “Start testing,” with the line “+ Shipping & handling,” and a separate “No monthly fees” claim. The FAQ says the membership renews on the cadence you select (monthly, quarterly, or every 6 months) and that you can change or cancel anytime. That FAQ does not print a renewal dollar amount. We will not invent one.
• Programs page, same day: GLP Optimization Panel +$75, Ultimate 360 +$125.
• How much does SiPhox Health cost? (Tsolmon Tsogbayar, MD; reviewed by Pavel Korecky, MD; 13 November 2025) says membership starts at $125 and that Ultimate 360 adds $100 for a $225 total, up to 60 biomarkers. That article is older than the live $124 CTA and the live +$125 Ultimate 360 label. Cite checkout at purchase time.

Nuvo: $4.99/month or $24.99/year ($2.08/month billed annually) after a 7-day trial. No kit and no mailed sample is bundled.

Those dollars buy different things. Say so. Many high-intent shoppers already spend the panel money; the remaining question is whether they also want a daily 21-biomarker biological age. That is the Nuvo add, not a rip-and-replace.

Frequently Asked Questions

Should I pick Nuvo or SiPhox Health?
Pick SiPhox Health if you want a periodic at-home blood membership: an upper-arm sample, a CLIA lab panel you can switch (Longevity Essentials, Thyroid Focus, Hormone Focus, Heart & Metabolic, or paid upgrades), results in about 7–10 days, and a biological age computed from blood biomarkers in a SiPhox account. The live homepage CTA on 28 September 2026 was $124 to start testing, plus shipping and handling; public pages disagree on upgrade totals, so confirm checkout. Pick Nuvo if you want a daily biological age from 21 biomarkers on iPhone and Apple Watch, optional conventional lab PDF in that same score, on-device AI, no account, and $24.99/year after a 7-day trial. If you already bought SiPhox, you can stack: SiPhox for the blood snapshot, Nuvo for the daily 21-biomarker trend.

Does SiPhox biological age use my Apple Watch?
Not as the clock. SiPhox’s August 2026 guides say Biological Age and Advanced Biological Age are calculated from blood biomarkers. Wearables, including Apple Watch, can sync sleep, activity, and heart rate into the SiPhox dashboard beside those labs. The biological-age guide says the blood score does not capture sleep quality or fitness. Nuvo’s daily biological age does use HealthKit from Apple Watch, Oura, or Garmin, plus optional labs, as one 21-biomarker score.

Is SiPhox biological age the same as PhenoAge, GlycanAge, or an epigenetic clock?
No. SiPhox’s own guide says Biological Age is their model of which age a blood-biomarker pattern resembles, trained on public data plus internal data, and that Advanced Biological Age is a VOLO Health outcome model translated into an age. They cite Liu et al. 2018 (phenotypic age from NHANES labs) and Levine et al. 2018 (DNAm PhenoAge) as further reading. Citing a paper is not the same as running that equation. GlycanAge is an IgG glycan kit. Nuvo is a daily 21-biomarker wearable-plus-optional-lab score. None of these are interchangeable.

How much do SiPhox Health and Nuvo cost?
On 28 September 2026 the SiPhox homepage CTA read $124 to start testing, plus shipping and handling. The programs page showed Ultimate 360 at +$125 and GLP Optimization at +$75. A 13 November 2025 SiPhox article prints $125 to start and $225 for Ultimate 360. We do not invent a renewal price or a single “true” total those pages do not share. Nuvo is $4.99/month or $24.99/year ($2.08/month billed annually) after a 7-day trial, with no kit required.

Can Nuvo use my SiPhox results?
Not as SiPhox Biological Age, Advanced Biological Age, or a named SiPhox input. Nuvo reads HealthKit and optional conventional lab PDFs (for example HbA1c, glucose, lipids, CRP). Keep the SiPhox age in the SiPhox dashboard. If you also have a standard blood-panel PDF, that PDF can go into Nuvo’s 21-biomarker score. You do not have to pick only one product.

How often does SiPhox update biological age if I use Nuvo daily?
SiPhox updates when you complete a membership test. Public cadence options are monthly, quarterly, or every 6 months, with about 7–10 days after the sample is in the lab. Nuvo recalculates daily, so it fills the gap between panels. It does not replace a SiPhox retest if the blood-biomarker age is the clock you care about.

Does Nuvo require an account?
No. Nuvo uses on-device private AI and no account. Apple’s privacy label is Data Not Collected; data stays on the phone. SiPhox requires an account to buy the membership and view lab results. Nuvo uses 21 longevity biomarkers (HealthKit plus optional labs such as HbA1c, fasting glucose, HDL, CRP, creatinine). SiPhox’s panel sizes are a different assay: the programs page labels Longevity Essentials at 35 biomarkers and Ultimate 360 at 65, while the homepage FAQ says Ultimate 360 is up to 60.

Is this medical advice?
No. This comparison is educational. Neither SiPhox nor Nuvo replaces care, diagnosis, or treatment from a licensed clinician. SiPhox’s biological-age guide says the score is not a medical diagnosis and should not be used alone to diagnose or treat any condition. Lab results and wearable scores should be reviewed with a qualified professional.

If the job is a daily biological age from 21 biomarkers on the iPhone and Apple Watch you already own, Download app.